Abstract
The authors measured CSF concentrations of corticotropin-releasing hormone (CRH) and arginine vasopressin in nine depressed patients before and after fluoxetine treatment. They found significant decreases in CSF CRH, CSF arginine vasopressin, and Hamilton depression ratings. Thus, the therapeutic effect of this serotonin-uptake inhibitor may be related to diminution of these arousal-promoting neuropeptides.
MeSH terms
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Adult
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Arginine Vasopressin / cerebrospinal fluid*
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Corticotropin-Releasing Hormone / cerebrospinal fluid*
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Depression, Chemical
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Depressive Disorder / cerebrospinal fluid
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Depressive Disorder / drug therapy*
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Depressive Disorder / psychology
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Female
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Fluoxetine / pharmacology
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Fluoxetine / therapeutic use*
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Humans
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Male
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Psychiatric Status Rating Scales
Substances
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Fluoxetine
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Arginine Vasopressin
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Corticotropin-Releasing Hormone