Abstract
Pancreatic polypeptide (PP) dose-dependently enhanced both basal and submaximally ACTH-stimulated corticosterone production by dispersed zona fasciculata/reticularis cells of the rat adrenal gland. Conversely PP did not affect either basal or ACTH- and angiotensin-II-stimulated aldosterone and corticosterone secretion of zona glomerulosa cells. These findings could throw light on the physiological significance of the marked increase in the pancreatic release of PP during stresses.
MeSH terms
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Adrenocorticotropic Hormone / pharmacology
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Aldosterone / metabolism
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Angiotensin II / pharmacology
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Animals
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Cells, Cultured
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Corticosterone / metabolism*
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Kinetics
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Male
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Pancreatic Polypeptide / pharmacology*
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Rats
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Rats, Wistar
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Stimulation, Chemical
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Zona Fasciculata / cytology
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Zona Fasciculata / drug effects*
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Zona Fasciculata / metabolism*
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Zona Reticularis / cytology
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Zona Reticularis / drug effects*
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Zona Reticularis / metabolism*
Substances
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Angiotensin II
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Aldosterone
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Pancreatic Polypeptide
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Adrenocorticotropic Hormone
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Corticosterone