Abstract
We have studied the effect of low-dose heparin on GVHD, marrow engraftment and graft-versus-leukemia (GVL) effects in an experimental murine model. Recipient (C57BL/6 x BALB/c) F1 mice were transplanted with C57BL/6 marrow and/or spleen cells and treated with daily sc injection of 5 micrograms heparin for 30 days. We have shown that heparin in low doses attenuates the severity of acute GVHD and reduces the mortality rate from 69 to 37.5% without abrogating the GVL effect induced by the allograft and without impairing marrow engraftment.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Disease
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Animals
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Bone Marrow Transplantation / adverse effects*
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Bone Marrow Transplantation / immunology
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Graft Survival / drug effects
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Graft vs Host Disease / prevention & control*
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Heparin / administration & dosage
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Heparin / pharmacology
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Heparin / therapeutic use*
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Injections, Subcutaneous
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Leukemia, Experimental / immunology*
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Leukemia, Experimental / surgery
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Male
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Mice
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Mice, Inbred BALB C / immunology
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Mice, Inbred C57BL / immunology
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Radiation Chimera
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Spleen / transplantation
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T-Lymphocytes / drug effects
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T-Lymphocytes / immunology