Cardiac preconditioning. Induction of endogenous tolerance to ischemia-reperfusion injury

Arch Surg. 1993 Nov;128(11):1208-11. doi: 10.1001/archsurg.1993.01420230036005.

Abstract

Cardiac preconditioning is a phenomenon by which a brief exposure to ischemia renders the heart more tolerant of a subsequent sustained ischemic insult. Understanding the mechanism involved may allow pharmacologic access to this protective state before cardiopulmonary bypass surgery and transplantation. We discuss herein the preconditioning phenomenon, the potential mechanisms involved, and the therapeutic implications of cardiac preconditioning.

Publication types

  • Review

MeSH terms

  • Adenosine / pharmacology
  • Adenosine / physiology
  • Adenosine / therapeutic use
  • Animals
  • Disease Models, Animal
  • Dogs
  • Drug Evaluation, Preclinical
  • Energy Metabolism
  • Humans
  • Myocardial Infarction / drug therapy
  • Myocardial Infarction / metabolism
  • Myocardial Infarction / prevention & control
  • Myocardial Ischemia / metabolism*
  • Myocardial Reperfusion Injury / drug therapy*
  • Myocardial Reperfusion Injury / metabolism*
  • Myocardial Reperfusion Injury / prevention & control
  • Myocardial Stunning / drug therapy
  • Myocardial Stunning / metabolism
  • Myocardial Stunning / prevention & control
  • Phenylephrine / pharmacology
  • Phenylephrine / therapeutic use
  • Protein Kinase C / physiology
  • Rats
  • Receptors, Adrenergic, alpha / drug effects
  • Receptors, Purinergic P1 / drug effects
  • Signal Transduction / drug effects

Substances

  • Receptors, Adrenergic, alpha
  • Receptors, Purinergic P1
  • Phenylephrine
  • Protein Kinase C
  • Adenosine