Evidence for a role of metabotropic glutamate receptors in sustained nociceptive inputs to rat dorsal horn neurons

Neuropharmacology. 1994 Jan;33(1):141-4. doi: 10.1016/0028-3908(94)90109-0.

Abstract

Several antagonists at metabotropic glutamate (mGlu) receptors, when applied ionophoretically, inhibited the excitation of single dorsal horn neurons elicited by cutaneous administration of the C fibre-selective algogen, mustard oil. The selectivity and stereospecificity of AP3 isomers at mGlu, compared to NMDA receptors was confirmed on responses to agonists and matched by their effects on mustard oil-evoked activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cycloleucine / analogs & derivatives
  • Cycloleucine / pharmacology
  • Glutamates / pharmacology
  • Hindlimb / drug effects
  • Hindlimb / physiology
  • Isothiocyanates / pharmacology
  • Male
  • Neurons / drug effects
  • Neurons / physiology*
  • Neurotoxins / pharmacology
  • Nociceptors / drug effects
  • Nociceptors / physiology*
  • Pain Measurement / drug effects
  • Rats
  • Rats, Wistar
  • Receptors, Metabotropic Glutamate / antagonists & inhibitors
  • Receptors, Metabotropic Glutamate / drug effects
  • Receptors, Metabotropic Glutamate / physiology*
  • Spinal Cord / cytology
  • Spinal Cord / drug effects
  • Spinal Cord / physiology*

Substances

  • Glutamates
  • Isothiocyanates
  • Neurotoxins
  • Receptors, Metabotropic Glutamate
  • Cycloleucine
  • 1-amino-1,3-dicarboxycyclopentane
  • 2,4-methanoglutamate
  • allyl isothiocyanate