Inhibition of human CYP3A catalyzed 1'-hydroxy midazolam formation by ketoconazole, nifedipine, erythromycin, cimetidine, and nizatidine

Pharm Res. 1994 Jun;11(6):921-4. doi: 10.1023/a:1018906614320.
No abstract available

MeSH terms

  • Chromatography, High Pressure Liquid
  • Cimetidine / pharmacology*
  • Cytochrome P-450 Enzyme Inhibitors*
  • Cytochrome P-450 Enzyme System / metabolism
  • Erythromycin / pharmacology*
  • Humans
  • In Vitro Techniques
  • Ketoconazole / pharmacology*
  • Microsomes, Liver / drug effects
  • Microsomes, Liver / enzymology
  • Midazolam / analogs & derivatives*
  • Midazolam / metabolism
  • Nifedipine / pharmacology*
  • Nizatidine / pharmacology*

Substances

  • Cytochrome P-450 Enzyme Inhibitors
  • Erythromycin
  • Cimetidine
  • Cytochrome P-450 Enzyme System
  • 1-hydroxymethylmidazolam
  • Nifedipine
  • Nizatidine
  • Midazolam
  • Ketoconazole