Intrastriatal injection of cannabinoid receptor agonists induced turning behavior in mice

Pharmacol Biochem Behav. 1995 May;51(1):3-7. doi: 10.1016/0091-3057(94)00396-z.

Abstract

When injected unilaterally into the mouse striatum, cannabinoid agonists such as Win 55212-2 (1-100 ng/mouse), CP 55940 (0.1-50 ng/mouse), and anandamide (0.5-50 ng/mouse), the putative endogenous ligand of CB1 receptor, dose-dependently induced turning behavior. SR 141716A [N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-me thyl-1H- pyrazole-3-carboxamide hydrochloride], the selective antagonist of CB1 receptor, antagonized the three cannabinoid receptor agonists-induced turning with similar ED50s (0.13-0.15 mg/kg, IP). Spiroperidol (a D2 receptor blocker), (+)-SCH 23390 (a D1 receptor blocker), or prior 6-OHDA lesions of the striatum blocked Win 55212-2- and CP 55940-induced turning, thus suggesting the involvement of DA transmission in cannabinoid-induced turning. Taken together, these findings reinforce the notion of a cannabinoid receptor-mediated control of nigrostriatal function.

MeSH terms

  • Analgesics / pharmacology
  • Animals
  • Benzoxazines
  • Cannabis / metabolism*
  • Corpus Striatum / metabolism
  • Corpus Striatum / physiology*
  • Cyclohexanols / administration & dosage
  • Cyclohexanols / pharmacology
  • Dose-Response Relationship, Drug
  • Female
  • Injections
  • Mice
  • Morpholines / administration & dosage
  • Morpholines / pharmacology
  • Naphthalenes / administration & dosage
  • Naphthalenes / pharmacology
  • Neurons / drug effects
  • Oxidopamine / toxicity
  • Piperidines / administration & dosage
  • Piperidines / pharmacology
  • Pyrazoles / administration & dosage
  • Pyrazoles / pharmacology
  • Receptors, Cannabinoid
  • Receptors, Drug / agonists*
  • Receptors, Neurokinin-2 / antagonists & inhibitors
  • Rimonabant
  • Stereoisomerism
  • Stereotyped Behavior / drug effects*

Substances

  • Analgesics
  • Benzoxazines
  • Cyclohexanols
  • Morpholines
  • Naphthalenes
  • Piperidines
  • Pyrazoles
  • Receptors, Cannabinoid
  • Receptors, Drug
  • Receptors, Neurokinin-2
  • (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone
  • 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol
  • Oxidopamine
  • Rimonabant