Abstract
Following peripheral axotomy, long-lasting changes in the expression of neuropeptides and their receptors in primary sensory neurons are observed. These changes involve the downregulation of the excitatory peptides substance P and calcitonin gene-related peptide and the upregulation of the inhibitory peptides neuropeptide tyrosine and galanin, resulting in a reduction of transmission in the dorsal horn. The changes observed are thought to represent adaptive responses to limit the consequences of peripheral nerve damage to the organism as a whole and to promote survival and recovery of the individual neuron.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptation, Physiological
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Animals
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Axons*
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Gene Expression Regulation*
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Macaca mulatta
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Models, Neurological
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Nerve Tissue Proteins / biosynthesis*
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Nerve Tissue Proteins / genetics
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Neurons, Afferent / metabolism*
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Neuropeptides / biosynthesis*
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Neuropeptides / genetics
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Nitric Oxide / physiology
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Pain / physiopathology
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Peripheral Nerve Injuries*
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RNA, Messenger / biosynthesis
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Rats
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Receptors, Neurotransmitter / biosynthesis*
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Receptors, Neurotransmitter / genetics
Substances
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Nerve Tissue Proteins
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Neuropeptides
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RNA, Messenger
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Receptors, Neurotransmitter
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Nitric Oxide