Prediction of drug-drug interaction from in vitro plasma protein binding and metabolism. A study of tolbutamide-sulfonamide interaction in rats

Biochem Pharmacol. 1981 Dec 15;30(24):3347-54. doi: 10.1016/0006-2952(81)90611-0.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Proteins / metabolism*
  • Drug Interactions
  • Half-Life
  • Male
  • Mathematics
  • Metabolic Clearance Rate
  • Rats
  • Rats, Inbred Strains
  • Sulfadimethoxine / blood
  • Sulfamethoxazole / blood
  • Sulfaphenazole / blood
  • Sulfonamides / blood*
  • Tolbutamide / blood*

Substances

  • Blood Proteins
  • Sulfonamides
  • Sulfaphenazole
  • Sulfadimethoxine
  • Tolbutamide
  • Sulfamethoxazole