Abstract
A new, potent hypocholesterolemic agent is produced by cultures of Aspergillus terreus. The isolation of the compound and its characterization as 4a,5-dihydromevinolin containing a trans-fused octahydro-naphthalene system are described. Comparative data for dihydromevinolin and mevinolin in three biological assays are given: in vitro inhibition of HMG-CoA reductase, inhibition of sterol synthesis in cell cultures, and inhibition of cholesterol synthesis in vivo in rats.
MeSH terms
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Animals
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Anticholesteremic Agents / metabolism*
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Aspergillus / metabolism*
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Cholesterol / biosynthesis
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Desmosterol / biosynthesis
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Hydroxymethylglutaryl-CoA Reductase Inhibitors*
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In Vitro Techniques
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Lovastatin* / analogs & derivatives*
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Molecular Conformation
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Naphthalenes / biosynthesis*
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Naphthalenes / pharmacology
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Rats
Substances
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Anticholesteremic Agents
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Hydroxymethylglutaryl-CoA Reductase Inhibitors
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Naphthalenes
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Desmosterol
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dihydromevinolin
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Cholesterol
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Lovastatin