Abstract
Clonidine and the 4 clonidine-like drugs: 44-549, lofexidine, guanfacine, and CP-14,304-18, had anticonvulsant activity against pentylenetetrazole-induced convulsions in rats. The magnitude and dose range over which anticonvulsant effects were observed was related to the selectivity of the compounds for alpha 2 and alpha 1 adrenoceptors. Selective alpha 2 adrenoceptor agonists may form a new group of anticonvulsants.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anticonvulsants*
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Cerebral Cortex / drug effects
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Cerebral Cortex / physiology
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Cerebral Cortex / physiopathology*
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Clonidine / analogs & derivatives*
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Clonidine / pharmacology*
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Female
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Male
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Pentylenetetrazole
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Prazosin / pharmacology
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Rats
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Rats, Inbred Strains
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Receptors, Adrenergic / physiology*
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Receptors, Adrenergic, alpha / drug effects
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Receptors, Adrenergic, alpha / physiology*
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Seizures / physiopathology
Substances
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Anticonvulsants
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Receptors, Adrenergic
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Receptors, Adrenergic, alpha
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Clonidine
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Pentylenetetrazole
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Prazosin