Abstract
Afferent fibers ending in nerve end neuromas in rats generate a substantial ectopic discharge and are sensitive to light pressure and to circulating adrenaline. Treatment of the nerve with colchicine or vinblastine at the time of the nerve section resulted in a dose-dependent reduction in the extent of this discharge. Such treatment also reduced neuroma discharge that had already gotten underway.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Axonal Transport* / drug effects
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Axons / physiology
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Colchicine / pharmacology
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Epinephrine / pharmacology
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Male
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Nerve Block
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Nerve Endings / physiology
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Neuroma / physiopathology
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Neurons, Afferent / physiology*
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Pain / physiopathology
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Peripheral Nerve Injuries*
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Peripheral Nervous System Neoplasms / physiopathology
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Rats
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Synaptic Transmission
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Vinblastine / pharmacology
Substances
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Vinblastine
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Colchicine
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Epinephrine