Abstract
Intraventricular administration of serotonin to rats causes 'wet-dog' shakes, a sign of morphine withdrawal. The frequency of shakes is dose-dependent. Shaking is potentiated by pretreatment with an inhibitor of monoamine oxidase or with 5,7-dihydroxytryptamine, and is depressed by morphine or serotonin receptor blockers. Depression of serotonin-induced shaking by morphine is reversed rapidly by naloxone. However, naloxone did not reverse the inhibition of 'wet-dog' shakes caused by serotonin receptor blockers.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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5,7-Dihydroxytryptamine / pharmacology
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Animals
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Brain / drug effects*
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Brain / metabolism
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Dopamine / metabolism
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Dose-Response Relationship, Drug
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Humans
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Injections, Intraventricular
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Male
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Mianserin / pharmacology
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Morphine / pharmacology*
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Naloxone / pharmacology
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Norepinephrine / metabolism
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Rats
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Receptors, Serotonin / drug effects
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Serotonin / administration & dosage
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Serotonin / metabolism
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Serotonin / pharmacology*
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Serotonin Antagonists
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Substance Withdrawal Syndrome
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Tranylcypromine / pharmacology
Substances
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Receptors, Serotonin
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Serotonin Antagonists
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Mianserin
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5,7-Dihydroxytryptamine
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Serotonin
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Naloxone
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Tranylcypromine
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Morphine
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Dopamine
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Norepinephrine