Interactions of spironolactone with hepatic microsomal drug-metabolizing enzyme systems

Biochem Pharmacol. 1971 Aug;20(8):1991-2000. doi: 10.1016/0006-2952(71)90398-4.
No abstract available

MeSH terms

  • Animals
  • Cytochromes / metabolism*
  • Dealkylation
  • Drug Antagonism
  • Electron Transport / drug effects
  • Enzyme Induction*
  • Hexobarbital / metabolism
  • In Vitro Techniques
  • Male
  • Mice
  • Microsomes, Liver / enzymology*
  • Microsomes, Liver / metabolism
  • Morphinans / antagonists & inhibitors
  • Morphinans / metabolism
  • NADP
  • Oxidoreductases / metabolism*
  • Sleep / drug effects
  • Spironolactone / pharmacology*

Substances

  • Cytochromes
  • Morphinans
  • Spironolactone
  • NADP
  • Hexobarbital
  • Oxidoreductases