Abstract
Phenobarbital and Benzonal in anticonvulsive doses depress energy production by brain mitochondria of rats, with phenobarbital inhibiting NAD-dependent respiration and Benzonal oxidation of succinate.
MeSH terms
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3-Hydroxybutyric Acid
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Animals
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Anticonvulsants / pharmacology*
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Barbiturates / pharmacology*
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Brain / drug effects*
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Brain / enzymology
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Hydroxybutyrates / metabolism
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In Vitro Techniques
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Ketoglutaric Acids / metabolism*
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Male
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Mitochondria / drug effects*
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Mitochondria / enzymology
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NAD / metabolism
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Oxidation-Reduction / drug effects
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Oxygen Consumption / drug effects
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Phenobarbital / pharmacology*
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Rats
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Succinate Dehydrogenase / metabolism
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Succinates / metabolism*
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Succinic Acid
Substances
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Anticonvulsants
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Barbiturates
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Hydroxybutyrates
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Ketoglutaric Acids
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Succinates
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NAD
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Succinic Acid
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Succinate Dehydrogenase
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3-Hydroxybutyric Acid
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benzobarbital
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Phenobarbital