Abstract
Corticotropin releasing factor (CRF) and sauvagine (SVG) when injected ICV both reduced aggressive behavior and sociability while increasing defensive behavior in isolated DBA/2 mice interacting with a group-housed intruder. SVG was more effective than CRF in producing such behavioral effects. These results add further evidence to the similarity between CRF and SVG, and are discussed in terms of the involvement of these peptides in emotional reactivity in the laboratory mouse.
MeSH terms
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Aggression / drug effects
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Amphibian Proteins
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Animals
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Cerebral Ventricles / drug effects
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Cerebral Ventricles / physiology*
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Corticotropin-Releasing Hormone / administration & dosage
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Corticotropin-Releasing Hormone / pharmacology*
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Injections, Intraventricular
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Male
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Mice
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Peptide Hormones
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Peptides / administration & dosage
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Peptides / pharmacology*
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Social Behavior*
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Social Isolation*
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Vasodilator Agents / pharmacology
Substances
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Amphibian Proteins
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Peptide Hormones
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Peptides
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Vasodilator Agents
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sauvagine
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Corticotropin-Releasing Hormone