Abstract
An endogenous ligand for the rat central sulfonylurea receptor has been evidenced in the rat central nervous system. The characteristics of this ligand (extractibility, non-dialysability, chromatographic behaviour on different media, sensitivity to proteases) indicate that it is a neutral to slightly basic peptide.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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ATP-Binding Cassette Transporters*
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Animals
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Cell Membrane / analysis
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Cell Membrane / metabolism
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Cerebral Cortex / analysis*
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Cerebral Cortex / metabolism
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Chromatography, High Pressure Liquid
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Chromatography, Ion Exchange
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Glipizide / metabolism
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Hydrogen-Ion Concentration
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Male
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Molecular Weight
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Papain / pharmacology
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Pepsin A / pharmacology
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Peptides / analysis*
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Peptides / metabolism
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Phospholipases A / pharmacology
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Potassium Channels*
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Potassium Channels, Inwardly Rectifying*
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Rats
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Rats, Inbred Strains
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Receptors, Drug / metabolism*
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Sulfonylurea Receptors
Substances
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ATP-Binding Cassette Transporters
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Peptides
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Potassium Channels
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Potassium Channels, Inwardly Rectifying
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Receptors, Drug
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Sulfonylurea Receptors
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Phospholipases A
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Papain
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Pepsin A
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Glipizide