Abstract
Amino-acid sequences derived from complementary DNAs encoding the alpha- and beta-subunits of the GABA/benzodiazepine receptor from bovine brain show homology with other ligand-gated receptor subunits, suggesting that there is a super-family of ion-channel-containing receptors. Co-expression of the in vitro-generated alpha-subunit and beta-subunit RNAs in Xenopus oocytes produces a functional receptor and ion channel with the pharmacological properties characteristic of the GABAA receptor.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cattle
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Cloning, Molecular
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DNA / genetics
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Gene Expression Regulation
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Membrane Proteins / genetics
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Multigene Family
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Oocytes / physiology
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Protein Conformation
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Receptors, GABA-A / genetics*
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Receptors, GABA-A / physiology
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Receptors, Nicotinic / genetics
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gamma-Aminobutyric Acid / physiology*
Substances
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Membrane Proteins
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Receptors, GABA-A
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Receptors, Nicotinic
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gamma-Aminobutyric Acid
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DNA
Associated data
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GENBANK/X05717
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GENBANK/X05718