Bioactivation of nephrotoxic haloalkenes by glutathione conjugation: formation of toxic and mutagenic intermediates by cysteine conjugate beta-lyase

Drug Metab Rev. 1989;20(1):43-83. doi: 10.3109/03602538908994144.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Alkenes / metabolism
  • Alkenes / toxicity*
  • Animals
  • Biotransformation
  • Carbon-Sulfur Lyases*
  • Glutathione / metabolism*
  • Humans
  • Hydrocarbons, Halogenated / metabolism
  • Hydrocarbons, Halogenated / toxicity*
  • Kidney Diseases / chemically induced*
  • Kidney Diseases / metabolism
  • Lyases / metabolism*
  • Mutagens / metabolism*

Substances

  • Alkenes
  • Hydrocarbons, Halogenated
  • Mutagens
  • Lyases
  • Carbon-Sulfur Lyases
  • cysteine lyase
  • Glutathione