Hippo-YAP and mTOR pathways collaborate to regulate organ size

Nat Cell Biol. 2012 Dec;14(12):1244-5. doi: 10.1038/ncb2634.

Abstract

Regulation of organ size is achieved through the action of the mTOR and Hippo signalling pathways, which control cell proliferation and cell growth in response to extracellular cues. A link between these pathways is revealed by the finding that YAP downregulates PTEN to promote cell growth and tissue hyperplasia.

Publication types

  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism*
  • Animals
  • Cell Cycle Proteins
  • Hepatocyte Growth Factor / metabolism*
  • Humans
  • Male
  • MicroRNAs / metabolism*
  • Phosphoproteins / metabolism*
  • Protein Serine-Threonine Kinases / metabolism*
  • Proto-Oncogene Proteins / metabolism*
  • Serine-Threonine Kinase 3
  • YAP-Signaling Proteins

Substances

  • Adaptor Proteins, Signal Transducing
  • Cell Cycle Proteins
  • MIRN29 microRNA, mouse
  • MicroRNAs
  • Phosphoproteins
  • Proto-Oncogene Proteins
  • YAP-Signaling Proteins
  • Yap1 protein, mouse
  • macrophage stimulating protein
  • Hepatocyte Growth Factor
  • Protein Serine-Threonine Kinases
  • Serine-Threonine Kinase 3
  • Stk3 protein, mouse