Abstract
Regulation of organ size is achieved through the action of the mTOR and Hippo signalling pathways, which control cell proliferation and cell growth in response to extracellular cues. A link between these pathways is revealed by the finding that YAP downregulates PTEN to promote cell growth and tissue hyperplasia.
MeSH terms
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Adaptor Proteins, Signal Transducing / metabolism*
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Animals
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Cell Cycle Proteins
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Hepatocyte Growth Factor / metabolism*
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Humans
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Male
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MicroRNAs / metabolism*
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Phosphoproteins / metabolism*
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Protein Serine-Threonine Kinases / metabolism*
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Proto-Oncogene Proteins / metabolism*
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Serine-Threonine Kinase 3
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YAP-Signaling Proteins
Substances
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Adaptor Proteins, Signal Transducing
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Cell Cycle Proteins
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MIRN29 microRNA, mouse
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MicroRNAs
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Phosphoproteins
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Proto-Oncogene Proteins
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YAP-Signaling Proteins
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Yap1 protein, mouse
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macrophage stimulating protein
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Hepatocyte Growth Factor
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Protein Serine-Threonine Kinases
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Serine-Threonine Kinase 3
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Stk3 protein, mouse