Interleukin-10 and interleukin-10-receptor defects in inflammatory bowel disease

Neil Shah; Jochen Kammermeier; Mamoun Elawad; Erik-Oliver Glocker

doi:10.1007/s11882-012-0286-z

Interleukin-10 and interleukin-10-receptor defects in inflammatory bowel disease

Curr Allergy Asthma Rep. 2012 Oct;12(5):373-9. doi: 10.1007/s11882-012-0286-z.

Authors

Neil Shah¹, Jochen Kammermeier, Mamoun Elawad, Erik-Oliver Glocker

Affiliation

¹ Department of Paediatric Gastroenterology, Great Ormond Street Hospital, University College London, London, UK.

PMID: 22890722
DOI: 10.1007/s11882-012-0286-z

Abstract

Inflammatory bowel disease (IBD) is a chronic inflammatory disease characterized by abdominal pain, bloody diarrhoea, and malabsorption leading to weight loss. It is considered the result of inadequate control of an excessive reaction of the immune system to the resident flora of the gut. Like other primary immunodeficiencies, IL-10 and IL-10 receptor (IL10R) deficiency present with IBD and demonstrate the sensitivity of the intestine to any changes of the immune system. Both IL-10 and IL10R deficiency cause severe early-onset enterocolitis and can be successfully treated by hematopoietic stem cell transplantation (HSCT).

Publication types

Review

MeSH terms

Diagnosis, Differential
Enterocolitis / immunology
Female
Gastrointestinal Tract / immunology*
Hematopoietic Stem Cell Transplantation
Humans
Inflammatory Bowel Diseases / diagnosis*
Inflammatory Bowel Diseases / immunology
Inflammatory Bowel Diseases / therapy*
Interferon-gamma / metabolism
Interleukin-10 / deficiency*
Interleukin-10 / genetics
Interleukin-22
Interleukins / metabolism
Male
Mutation*
Receptors, Interleukin-10 / deficiency*
Receptors, Interleukin-10 / genetics
STAT3 Transcription Factor / genetics
Signal Transduction / genetics

Substances

IL26 protein, human
Interleukins
Receptors, Interleukin-10
STAT3 Transcription Factor
STAT3 protein, human
Interleukin-10
Interferon-gamma