Fragile X syndrome therapeutics S(C)TEP through the developmental window

Aditi Bhattacharya; Eric Klann

doi:10.1016/j.neuron.2012.03.014

Fragile X syndrome therapeutics S(C)TEP through the developmental window

Neuron. 2012 Apr 12;74(1):1-3. doi: 10.1016/j.neuron.2012.03.014.

Authors

Aditi Bhattacharya¹, Eric Klann

Affiliation

¹ Center for Neural Science, New York University, New York, NY 10003, USA.

PMID: 22500622
DOI: 10.1016/j.neuron.2012.03.014

Abstract

Treatment for fragile X syndrome and related autism spectrum disorders has long been thought to be effective only during a narrow window early in development. In this issue of Neuron, Michalon et al. (2012) dispel this myth.

Publication types

Comment

MeSH terms

Animals
Excitatory Amino Acid Antagonists / therapeutic use*
Fragile X Syndrome / drug therapy*
Imidazoles / therapeutic use*
Male
Pyridines / therapeutic use*
Receptor, Metabotropic Glutamate 5
Receptors, Metabotropic Glutamate / drug effects*

Substances

2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridine
Excitatory Amino Acid Antagonists
Imidazoles
Pyridines
Receptor, Metabotropic Glutamate 5
Receptors, Metabotropic Glutamate