Abstract
The effects of two high-affinity sigma ligands, DTG (1,3-di(2-tolyl)guanidine) and haloperidol, on the activation of dorsal hippocampus pyramidal neurons induced by microiontophoretic application of N-methyl-D-aspartate (NMDA) were assessed electrophysiologically. Low doses of DTG (0.5-3 micrograms/kg i.v.) potentiated the NMDA response. This effect of DTG was blocked by haloperidol (10 micrograms/kg i.v.), but not by spiperone, a potent dopamine antagonist with low affinity for sigma receptors. These results suggest that sigma receptors modulate the NMDA-induced neuronal activation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Aspartic Acid / analogs & derivatives*
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Aspartic Acid / pharmacology
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Guanidines / pharmacology
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Haloperidol / pharmacology
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In Vitro Techniques
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Iontophoresis
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Kainic Acid / pharmacology
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Male
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N-Methylaspartate
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Neurons / drug effects*
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Oxadiazoles / pharmacology
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Quisqualic Acid
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Rats
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Rats, Inbred Strains
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Receptors, Opioid / physiology*
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Receptors, sigma
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Spiperone / pharmacology
Substances
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Guanidines
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Oxadiazoles
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Receptors, Opioid
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Receptors, sigma
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Aspartic Acid
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Spiperone
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N-Methylaspartate
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Quisqualic Acid
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Haloperidol
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1,3-ditolylguanidine
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Kainic Acid