First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase

Chem Commun (Camb). 2011 May 14;47(18):5295-7. doi: 10.1039/c1cc10787a. Epub 2011 Mar 31.

Abstract

Nerve agents are highly toxic organophosphorus compounds with strong inhibition potency against acetylcholinesterase (AChE). Herein, we describe two first extremely promising uncharged reactivators for poisoned human AChE with a superior or similar in vitro ability to reactivate the enzyme as compared to that of HI-6, obidoxime, TMB-4 and HLö-7.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholinesterase / metabolism
  • Cholinesterase Inhibitors / pharmacology*
  • Erythrocytes / enzymology*
  • Humans
  • Molecular Structure
  • Obidoxime Chloride / metabolism
  • Organophosphates / metabolism
  • Organophosphorus Compounds / chemistry*
  • Oximes / chemistry
  • Pyridines / pharmacology*
  • Pyridinium Compounds / pharmacology*
  • Soman / metabolism

Substances

  • Cholinesterase Inhibitors
  • Organophosphates
  • Organophosphorus Compounds
  • Oximes
  • Pyridines
  • Pyridinium Compounds
  • HLo 7
  • Obidoxime Chloride
  • Soman
  • Acetylcholinesterase
  • asoxime chloride
  • tabun