Polarization of tumor-associated macrophages: a novel strategy for vascular normalization and antitumor immunity

Yuhui Huang; Matija Snuderl; Rakesh K Jain

doi:10.1016/j.ccr.2011.01.005

Polarization of tumor-associated macrophages: a novel strategy for vascular normalization and antitumor immunity

Cancer Cell. 2011 Jan 18;19(1):1-2. doi: 10.1016/j.ccr.2011.01.005.

Authors

Yuhui Huang¹, Matija Snuderl, Rakesh K Jain

Affiliation

¹ Steele Lab of Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

Abstract

Vascular normalization is an emerging concept in cancer treatment. In this issue of Cancer Cell, Rolny et al. show that histidine-rich glycoprotein normalizes tumor vessels and promotes antitumor immunity by polarizing tumor-associated macrophages, leading to decreased tumor growth and metastasis. Placental Growth Factor deletion in macrophages phenocopies many of these effects.

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