SDF-1:CXCR4 axis is fundamental for tissue preservation and repair

Am J Pathol. 2010 Nov;177(5):2166-8. doi: 10.2353/ajpath.2010.100803. Epub 2010 Oct 1.

Author

Affiliation

¹ Skirball Laboratory for Cardiovascular Cellular Therapeutics, Department of Stem Cell Biology and Regenerative Medicine, Heart and Vascular Institute, Cleveland Clinic, J2-131, 9500 Euclid Ave., Cleveland, OH 44195, USA. pennm@ccf.org

Abstract

This Commentary discusses the role of the SDF-1:CXCR4 axis in tissue preservation and repair.

Publication types

Comment

MeSH terms

Cell- and Tissue-Based Therapy
Chemokine CXCL12 / metabolism*
Humans
Receptors, CXCR4 / metabolism*
Regeneration / physiology*
Retinal Detachment / pathology
Stem Cells / physiology

Substances

Chemokine CXCL12
Receptors, CXCR4