Animal model of systemic carnitine deficiency: analysis in C3H-H-2 degrees strain of mouse associated with juvenile visceral steatosis

Biochem Biophys Res Commun. 1991 Feb 14;174(3):1090-4. doi: 10.1016/0006-291x(91)91532-h.

Abstract

We analyzed carnitine profiles in C3H-H-2 degrees strain of mouse associated with fatty liver, hyperammonemia and hypoglycemia (Koizumi et al., 1988). Carnitine levels in serum, liver and muscle of mouse with fatty liver were markedly decreased in comparison with those of control mouse (littermates without fatty liver). This is a useful animal model to analyze the role of carnitine in lipid, amino acid and carbohydrate metabolism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging
  • Animals
  • Carnitine / blood
  • Carnitine / deficiency*
  • Carnitine / urine
  • Disease Models, Animal
  • Fatty Liver / metabolism*
  • Lipid Metabolism
  • Liver / growth & development
  • Liver / metabolism*
  • Mice
  • Mice, Inbred C3H
  • Mice, Mutant Strains
  • Muscle Development
  • Muscles / metabolism*
  • Reference Values

Substances

  • Carnitine