Cellular efflux of cAMP and cGMP - a question about selectivity

Georg Sager; Aina Westrheim Ravna

doi:10.2174/138955709788681654

Cellular efflux of cAMP and cGMP - a question about selectivity

Mini Rev Med Chem. 2009 Jul;9(8):1009-13. doi: 10.2174/138955709788681654.

Authors

Georg Sager¹, Aina Westrheim Ravna

Affiliation

¹ Faculty of Medicine, Institute of Medical Biology, Department of Pharmacology, University of Tromsø, N- 9037 Tromsø, Norway. georg.sager@fagmed.uit.no

PMID: 19601896
DOI: 10.2174/138955709788681654

Abstract

The present paper reviews and discusses selectivity of ABCC4 (MRP4), ABCC5 (MRP5) and ABCC11 (MRP8) as cellular efflux pumps for cAMP and cGMP. These transporters are potential drug targets for selective modulation of cyclic nucleotide action.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

ATP-Binding Cassette Transporters / antagonists & inhibitors
ATP-Binding Cassette Transporters / genetics
ATP-Binding Cassette Transporters / metabolism*
Animals
Cyclic AMP / metabolism*
Cyclic GMP / metabolism*
Humans
Models, Molecular
Substrate Specificity

Substances

ATP-Binding Cassette Transporters
Cyclic AMP
Cyclic GMP