Abstract
The ability for long-range communication through intercellular calcium waves is inherent to cells of many tissues. A dual propagation mode for these waves includes passage of IP3 through gap junctions as well as an extracellular pathway involving ATP. The wave can be regenerative and include ATP-induced ATP release via an unknown mechanism. Here, we show that pannexin 1 channels can be activated by extracellular ATP acting through purinergic receptors of the P2Y group as well as by cytoplasmic calcium. Based on its properties, including ATP permeability, pannexin 1 may be involved in both initiation and propagation of calcium waves.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Adenosine Triphosphate / pharmacology*
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Animals
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Calcium / metabolism*
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Calcium Signaling / drug effects*
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Cell Membrane Permeability / drug effects
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Connexins / genetics
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Connexins / metabolism*
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Female
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Humans
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Inositol Phosphates / metabolism
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Membrane Potentials / drug effects
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Nerve Tissue Proteins
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Oocytes
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Receptors, Purinergic P2 / genetics
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Receptors, Purinergic P2 / metabolism*
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Receptors, Purinergic P2Y1
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Xenopus
Substances
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Connexins
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Inositol Phosphates
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Nerve Tissue Proteins
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P2RY1 protein, human
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PANX1 protein, human
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Receptors, Purinergic P2
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Receptors, Purinergic P2Y1
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Adenosine Triphosphate
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Calcium