Regulation of glucocorticoid receptor steroid binding and trafficking by the hsp90/hsp70-based chaperone machinery: implications for clinical intervention

Leukemia. 2005 May;19(5):710-2. doi: 10.1038/sj.leu.2403687.
No abstract available

Publication types

  • Comment

MeSH terms

  • Benzoquinones
  • Drug Resistance
  • Enzyme Inhibitors / pharmacology
  • Glucocorticoids / pharmacology
  • HSP70 Heat-Shock Proteins / drug effects
  • HSP70 Heat-Shock Proteins / genetics
  • HSP70 Heat-Shock Proteins / metabolism*
  • HSP90 Heat-Shock Proteins / drug effects
  • HSP90 Heat-Shock Proteins / genetics
  • HSP90 Heat-Shock Proteins / metabolism*
  • Humans
  • Lactams, Macrocyclic
  • Molecular Chaperones / drug effects
  • Molecular Chaperones / genetics
  • Molecular Chaperones / metabolism*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism*
  • Protein Binding / physiology
  • Protein Transport / physiology
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Receptors, Glucocorticoid / metabolism*
  • Rifabutin / analogs & derivatives*
  • Rifabutin / pharmacology
  • Steroids / metabolism*

Substances

  • Benzoquinones
  • Enzyme Inhibitors
  • Glucocorticoids
  • HSP70 Heat-Shock Proteins
  • HSP90 Heat-Shock Proteins
  • Lactams, Macrocyclic
  • Molecular Chaperones
  • RNA, Messenger
  • Receptors, Glucocorticoid
  • Steroids
  • Rifabutin
  • tanespimycin