Abstract
We determined COX-3 mRNA expression in regions of the rat central nervous system (CNS). On a regional basis, levels were the highest in choroid plexus and spinal chord followed by pituitary gland, hypothalamus, hippocampus, medulla, cerebellum, and cortex. COX-3 mRNA levels were higher in major brain arteries, and dramatically higher in brain microvessels. Our results suggest that the expression pattern of COX-3 mRNA in the rat CNS primarily relates to the vascular density of a given region.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Brain / blood supply
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Brain / metabolism*
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Cyclooxygenase 1
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Male
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Membrane Proteins
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Prostaglandin-Endoperoxide Synthases / genetics*
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Prostaglandin-Endoperoxide Synthases / metabolism*
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RNA, Messenger / metabolism*
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Rats
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Rats, Wistar
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Spinal Cord / metabolism*
Substances
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Membrane Proteins
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RNA, Messenger
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Cyclooxygenase 1
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Prostaglandin-Endoperoxide Synthases
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Ptgs1 protein, rat
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cyclooxygenase-3