The neuro-dynamical characteristics of the higher nervous activity of senior pupils in different weather types were investigated. The group of practically healthy pupils was given tests on investigation of the speed of the simple sensomotorical reaction (SSR), sigma of the simple sensomotorical reaction (Sigma), the medial speed of the choice reaction (CR), the speed of the choice reaction for the right (CRR) and the left (CRL) hand. The study was conducted on the days with favorable, conditionally favorable and unfavorable medical-meteorological conditions. The results of the study of the neuro-dynamical characteristics of the higher nervous activity of senior pupils give the possibility to make a conclusion that they decrease as the weather conditions become worse. Senior school age is characterized by the improvement of the neuro-dynamical characteristics of the higher nervous activity. The girls of the senior school age have shown higher results in different weather types than the boys.