Use of in vitro drug metabolism data to evaluate metabolic drug-drug interactions in man: the need for quantitative databases

J Clin Pharmacol. 2001 Apr;41(4):368-73. doi: 10.1177/00912700122010212.

Abstract

It has become widely accepted that metabolic drug-drug interactions can be forecast using in vitro cytochrome P450 (CYP) data. For any CYP form-inhibitor pair, the magnitude of the interaction will depend on the potency of the inhibitor (inhibition constant, Ki) the concentration of the inhibitor available for inhibition ([I]), the fraction of the substrate dose metabolized by CYP (fm), and the fraction of the CYP-dependent metabolism catalyzed by the inhibited CYP form (e.g., fm,CYP3A4). While progress is being made toward our understanding of the factors necessary for predictions of [I]/Ki in vivo, it is evident that there is a need for quantitative databases that contain in vitro (e.g., Ki, fm,CYP3A4) and in vivo pharmacokinetic/absorption-distribution-metabolism-excretion (PK/ADME) data (e.g., fm) for a large number of marketed drugs. Ultimately, such databases would allow one to integrate all of the data necessary for the prediction of drug-drug interactions and permit the rational evaluation of new drug entities.

Publication types

  • Evaluation Study

MeSH terms

  • Cytochrome P-450 Enzyme System / metabolism
  • Databases, Factual*
  • Drug Design
  • Drug Interactions*
  • Humans
  • In Vitro Techniques
  • Isoenzymes / metabolism
  • Pharmacokinetics*
  • Sensitivity and Specificity

Substances

  • Isoenzymes
  • Cytochrome P-450 Enzyme System