Drug delivery via the blood-brain barrier

Nat Neurosci. 2001 Mar;4(3):221-2. doi: 10.1038/85045.

Abstract

The blood-brain barrier forms a buffer against the systemic circulation. Now drugs administered to the brain are shown to be exported by a transporter to act at peripheral sites.

Publication types

  • Review
  • Comment

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B / drug effects
  • ATP Binding Cassette Transporter, Subfamily B / metabolism
  • ATP-Binding Cassette Transporters / drug effects
  • ATP-Binding Cassette Transporters / metabolism
  • Animals
  • Blood-Brain Barrier / drug effects*
  • Blood-Brain Barrier / physiology
  • Brain / drug effects*
  • Brain / metabolism
  • Carrier Proteins / drug effects*
  • Carrier Proteins / metabolism
  • Humans

Substances

  • ATP Binding Cassette Transporter, Subfamily B
  • ATP-Binding Cassette Transporters
  • Carrier Proteins
  • multidrug resistance protein 3