Abstract
The blood-brain barrier forms a buffer against the systemic circulation. Now drugs administered to the brain are shown to be exported by a transporter to act at peripheral sites.
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B / drug effects
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ATP Binding Cassette Transporter, Subfamily B / metabolism
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ATP-Binding Cassette Transporters / drug effects
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ATP-Binding Cassette Transporters / metabolism
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Animals
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Blood-Brain Barrier / drug effects*
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Blood-Brain Barrier / physiology
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Brain / drug effects*
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Brain / metabolism
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Carrier Proteins / drug effects*
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Carrier Proteins / metabolism
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Humans
Substances
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ATP Binding Cassette Transporter, Subfamily B
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ATP-Binding Cassette Transporters
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Carrier Proteins
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multidrug resistance protein 3