Abstract
Zolpidem is an imidazopyridine with high affinity at gamma-aminobutyric acid(A) (GABA(A)) receptors expressing alpha1 subunits. In squirrel monkeys trained to discriminate a high dose of zolpidem (> or =3.0 mg/kg) from saline, zolpidem and another GABA(A)/alpha1 receptor-preferring agonist, zaleplon, substituted dose-dependently for zolpidem, whereas the non-selective agonists diazepam and triazolam were did not substitute at any dose tested. These findings offer the first evidence for a selective role of GABA(A)/alpha1 receptors in the interoceptive effects of high doses of zolpidem.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acetamides / pharmacology
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Animals
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Diazepam / pharmacology
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Discrimination, Psychological / drug effects*
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Dose-Response Relationship, Drug
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GABA Agonists / pharmacology*
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GABA Modulators / pharmacology
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GABA-A Receptor Agonists*
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Male
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Protein Subunits
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Pyridines / pharmacology*
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Pyrimidines / pharmacology
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Reinforcement Schedule
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Saimiri
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Triazolam / pharmacology
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Zolpidem
Substances
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Acetamides
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GABA Agonists
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GABA Modulators
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GABA-A Receptor Agonists
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Protein Subunits
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Pyridines
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Pyrimidines
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Triazolam
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Zolpidem
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Diazepam
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zaleplon