Evidence for involvement of prostaglandin I2 as a major nociceptive mediator in acetic acid-induced writhing reaction: a study using IP-receptor disrupted mice

Adv Exp Med Biol. 1999:469:265-8. doi: 10.1007/978-1-4615-4793-8_39.

Authors

S Ohishi¹, A Ueno, H Matsumoto, T Murata, F Ushikubi, S Narumiya

Affiliation

¹ Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University, Tokyo.

PMID: 10667340
DOI: 10.1007/978-1-4615-4793-8_39

No abstract available

MeSH terms

6-Ketoprostaglandin F1 alpha / metabolism
Acetic Acid / toxicity
Analgesics, Non-Narcotic / pharmacology
Animals
Ascitic Fluid / metabolism
Dinoprostone / metabolism
Epoprostenol / physiology*
Indomethacin / pharmacology
Male
Mice
Mice, Inbred ICR
Mice, Knockout
Nociceptors / drug effects
Nociceptors / physiology*
Pain / chemically induced
Pain / physiopathology*
Pain Measurement
Receptors, Epoprostenol
Receptors, Prostaglandin / drug effects
Receptors, Prostaglandin / genetics
Receptors, Prostaglandin / physiology*

Substances

Analgesics, Non-Narcotic
Receptors, Epoprostenol
Receptors, Prostaglandin
6-Ketoprostaglandin F1 alpha
Epoprostenol
Dinoprostone
Acetic Acid
Indomethacin