The novel Na+/Ca2+ exchange inhibitor KB-R7943 protects CA1 neurons in rat hippocampal slices against hypoxic/hypoglycemic injury

U H Schröder; J Breder; C F Sabelhaus; K G Reymann

doi:10.1016/s0028-3908(98)00198-1

The novel Na+/Ca2+ exchange inhibitor KB-R7943 protects CA1 neurons in rat hippocampal slices against hypoxic/hypoglycemic injury

Neuropharmacology. 1999 Feb;38(2):319-21. doi: 10.1016/s0028-3908(98)00198-1.

Authors

U H Schröder¹, J Breder, C F Sabelhaus, K G Reymann

Affiliation

¹ Project Group Neuropharmacology, Leibniz Institute for Neurobiology, Magdeburg, Germany. schroede@ifn-magdeburg.de

PMID: 10218875
DOI: 10.1016/s0028-3908(98)00198-1

Abstract

The selective Na+/Ca2+ exchange inhibitor 2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea methanesulfonate (KB-R7943), significantly improves recovery of population spike amplitudes in rat hippocampal slices after hypoxia/hypoglycemia. Our data suggest that the Na+/Ca2+ exchanger, operating in reverse mode, contributes to hypoxia/hypoglycemia-induced injury in CA1 neurons.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Hypoxia
Hippocampus / cytology
Hippocampus / drug effects*
Hippocampus / physiology
Hypoglycemia
In Vitro Techniques
Male
Membrane Potentials / drug effects
Neurons / cytology
Neurons / drug effects*
Neurons / physiology
Neuroprotective Agents / pharmacology
Rats
Rats, Wistar
Sodium-Calcium Exchanger / antagonists & inhibitors*
Thiourea / analogs & derivatives*
Thiourea / pharmacology

Substances

2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate
Neuroprotective Agents
Sodium-Calcium Exchanger
Thiourea