Abstract
Experiments with male mice (28-32 g) of the CFLP strain showed that cinnarizine in doses of 2.5, 5.0 or 10.0 mg kg-1 significantly inhibited the extent of ear oedema induced by croton oil, capsaicin or dithranol, in a dose-dependent manner. In rats of the Wistar strain, oedema was induced in the hind paw by subplantar injection of carrageenin, and simultaneously by the application of croton oil to the inner surface of the ear. Preliminary cinnarizine treatment (5, 10 or 20 mg kg-1) inhibited the development of both types of oedema, to a statistically significant extent, in a dose-dependent manner.
MeSH terms
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Administration, Topical
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Animals
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Anthralin / pharmacology
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Anti-Inflammatory Agents / pharmacology
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Blood Pressure / drug effects
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Calcium Channel Blockers / pharmacology*
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Calcium Channel Blockers / therapeutic use
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Capsaicin / pharmacology
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Carrageenan / pharmacology
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Cinnarizine / pharmacology*
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Cinnarizine / therapeutic use
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Croton Oil / pharmacology
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Dimethyl Sulfoxide / pharmacology
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Dose-Response Relationship, Drug
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Ear / pathology
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Edema / chemically induced
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Edema / prevention & control*
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Excipients / pharmacology
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Foot / pathology
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Hindlimb
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Injections, Intraperitoneal
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Irritants / pharmacology
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Male
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Mice
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Rats
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Rats, Wistar
Substances
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Anti-Inflammatory Agents
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Calcium Channel Blockers
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Excipients
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Irritants
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Cinnarizine
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Croton Oil
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Carrageenan
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Capsaicin
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Anthralin
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Dimethyl Sulfoxide