Generic placeholder image

Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Cellular Efflux of cAMP and cGMP - A Question about Selectivity

Author(s): Georg Sager and Aina Westrheim Ravna

Volume 9, Issue 8, 2009

Page: [1009 - 1013] Pages: 5

DOI: 10.2174/138955709788681654

Price: $65

Abstract

The present paper reviews and discusses selectivity of ABCC4 (MRP4), ABCC5 (MRP5) and ABCC11 (MRP8) as cellular efflux pumps for cAMP and cGMP. These transporters are potential drug targets for selective modulation of cyclic nucleotide action.

Keywords: cGMP, cAMP, ABCC4, ABCC5, ABCC11, transport selectivity


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy