Abstract
The poor permeability of cellular membrane is one of the principal hurdles of most drug administrations including vaccine system, consequently impairing drug efficiency. In order to address this natural barrier, cell-penetrating peptides (CPPs) have been developed to facilitate molecular cargos to enter cells. CPPs, generally short peptides with 5-30 amino acids, can be classified in to cationic, amphipathic and hydrophobic types according to physical-chemical properties. In this review, different processes of antigen uptake, subsequent processing and presentation of CPP-based vaccine are comprehensively summarized despite precise mechanisms are not still established. Some experimental factors such as cell types, concentration of CPPs and antigenic cargos have been reported to affect antigen uptake orientation. Moreover, this review discusses different antigenic cargos where CPPs can transport for vaccine delivery as well as the application of CPPs in vaccine system via different administration routes like transdermal, subcutaneous and mucosal immunization.
Keywords: Administration route, antigenic cargo, cell-penetrating peptide, vaccine delivery.
Current Pharmaceutical Biotechnology
Title:Cell-Penetrating Peptides as Delivery Enhancers for Vaccine
Volume: 15 Issue: 3
Author(s): Yuhong Jiang, Man Li, Zhirong Zhang, Tao Gong and Xun Sun
Affiliation:
Keywords: Administration route, antigenic cargo, cell-penetrating peptide, vaccine delivery.
Abstract: The poor permeability of cellular membrane is one of the principal hurdles of most drug administrations including vaccine system, consequently impairing drug efficiency. In order to address this natural barrier, cell-penetrating peptides (CPPs) have been developed to facilitate molecular cargos to enter cells. CPPs, generally short peptides with 5-30 amino acids, can be classified in to cationic, amphipathic and hydrophobic types according to physical-chemical properties. In this review, different processes of antigen uptake, subsequent processing and presentation of CPP-based vaccine are comprehensively summarized despite precise mechanisms are not still established. Some experimental factors such as cell types, concentration of CPPs and antigenic cargos have been reported to affect antigen uptake orientation. Moreover, this review discusses different antigenic cargos where CPPs can transport for vaccine delivery as well as the application of CPPs in vaccine system via different administration routes like transdermal, subcutaneous and mucosal immunization.
Export Options
About this article
Cite this article as:
Jiang Yuhong, Li Man, Zhang Zhirong, Gong Tao and Sun Xun, Cell-Penetrating Peptides as Delivery Enhancers for Vaccine, Current Pharmaceutical Biotechnology 2014; 15 (3) . https://dx.doi.org/10.2174/1389201015666140813130114
DOI https://dx.doi.org/10.2174/1389201015666140813130114 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
Call for Papers in Thematic Issues
Artificial Intelligence in Bioinformatics
Bioinformatics is an interdisciplinary field that analyzes and explores biological data. This field combines biology and information system. Artificial Intelligence (AI) has attracted great attention as it tries to replicate human intelligence. It has become common technology for analyzing and solving complex data and problems and encompasses sub-fields of machine ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Genetics and Genomics of Hepatic Acute Phase Reactants: A Mini-Review
Inflammation & Allergy - Drug Targets (Discontinued) The Chemical Structure and Bioactivity of Cycloartane-type Compounds
Current Organic Chemistry AFM Applications to the Analysis of Plasma-Treated Surface Growth and Nanocomposite Materials
Current Nanoscience Sex Hormones and their Analogues in Neuroimmune Biology
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Alpha-Terpineol as Antitumor Candidate in Pre-Clinical Studies
Anti-Cancer Agents in Medicinal Chemistry Condition Optimization and Production of Extracellular l-Arginine Deiminase from Vibrio Alginolyticus 1374
Current Biotechnology Nitrogen Mustards as Anticancer Chemotherapies: Historic Perspective, Current Developments and Future Trends
Current Topics in Medicinal Chemistry Variability in the Response to Non-pharmacological Treatments in Patients with Cardiovascular Diseases
Current Pharmacogenomics and Personalized Medicine Bioavailability of Endomorphins and the Blood-brain Barrier- A Review
Medicinal Chemistry Neurokinin-1 Receptor Antagonists as Anticancer Drugs
Letters in Drug Design & Discovery Poly(ADP-Ribose) Polymerase Inhibitors: New Pharmacological Functions and Potential Clinical Implications
Current Pharmaceutical Design Effect of Botanicals on Inflammation and Skin Aging: Analyzing the Evidence
Inflammation & Allergy - Drug Targets (Discontinued) Ribozyme- and Deoxyribozyme-Strategies for Medical Applications
Current Drug Targets Estrogen, Immunity & Autoimmune Disease
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Membrane Transporters in Physiological Barriers of Pharmacological Importance
Current Pharmaceutical Design Promotion of Optimized Protein Therapy by Bioconjugation as a Polymeric DDS
Anti-Cancer Agents in Medicinal Chemistry Current Treatment Options for HCC: From Pharmacokinetics to Efficacy and Adverse Events in Liver Cirrhosis
Current Drug Metabolism Modulation of Neutrophil Development and Homeostasis
Current Molecular Medicine Aurora Kinase Inhibitors in Head and Neck Cancer
Current Topics in Medicinal Chemistry Mitogen Activated Protein (MAP) Kinases: Development of ATP and Non- ATP Dependent Inhibitors
Medicinal Chemistry