Arginine-rich Peptides: Methods of Translocation Through Biological Membranes

Shiroh      Futaki; Hisaaki      Hirose; Ikuhiko      Nakase

Abstract

Intracellular delivery using cell-penetrating peptides (CPPs) has received considerable attention as a promising method for introducing exogenous molecules into cells. The mechanisms that enable efficient internalization of CPPs together with cargo molecules are also of interest. In this review, we describe our current views of membrane translocation of CPPs, especially those rich in arginine, as these peptides represent one of the most frequently employed classes of CPPs.

Keywords: Cell-penetrating peptide, arginine, macropinocytosis, membrane-associated proteoglycan, direct translocation, membrane potential, counterion, membrane curvature

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Current Pharmaceutical Design

Title:Arginine-rich Peptides: Methods of Translocation Through Biological Membranes

Volume: 19 Issue: 16

Author(s): Shiroh Futaki, Hisaaki Hirose and Ikuhiko Nakase

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Keywords: Cell-penetrating peptide, arginine, macropinocytosis, membrane-associated proteoglycan, direct translocation, membrane potential, counterion, membrane curvature

Abstract: Intracellular delivery using cell-penetrating peptides (CPPs) has received considerable attention as a promising method for introducing exogenous molecules into cells. The mechanisms that enable efficient internalization of CPPs together with cargo molecules are also of interest. In this review, we describe our current views of membrane translocation of CPPs, especially those rich in arginine, as these peptides represent one of the most frequently employed classes of CPPs.

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Cite this article as:

Futaki Shiroh, Hirose Hisaaki and Nakase Ikuhiko, Arginine-rich Peptides: Methods of Translocation Through Biological Membranes, Current Pharmaceutical Design 2013; 19 (16) . https://dx.doi.org/10.2174/1381612811319160003

DOI https://dx.doi.org/10.2174/1381612811319160003	Print ISSN 1381-6128
Publisher Name Bentham Science Publisher	Online ISSN 1873-4286

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