Hypertension Research
Online ISSN : 1348-4214
Print ISSN : 0916-9636
ISSN-L : 0916-9636
Experimental studies
Differential Induction of Protein Kinase C Isoforms at the Cardiac Hypertrophy Stage and Congestive Heart Failure Stage in Dahl Salt-Sensitive Rats
Yuichi KOIDEKouichi TAMURAAtsushi SUZUKIKouichi KITAMURAKeiko YOKOYAMATatsuo HASHIMOTONobuhito HIRAWAMinoru KIHARAOHNOShigeoSatoshi UMEMURA
Author information
JOURNAL FREE ACCESS

2003 Volume 26 Issue 5 Pages 421-426

Details
Abstract

Several protein kinase C (PKC) isoforms may play important roles in cellular signaling pathways. Recent reports have suggested that PKC plays critical isoform-specific roles in the development of cardiac hypertrophy and heart failure. The purpose of the present study was to examine the expression profiles of PKC isoforms in models of cardiac hypertrophy and heart failure. We examined the cardiac expression of individual PKC isoforms at the cardiac hypertrophy stage and the heart failure stage in Dahl salt-sensitive rats by Western blot analysis. The levels of all PKC isoforms increased at the cardiac hypertrophy stage and the heart failure stage, but the pattern of increase differed among PKC isoforms at the heart failure stage. The expressions of PKCα, β, and δ increased at the cardiac hypertrophy stage and remained elevated at the heart failure stage. On the other hand, the expression of PKCε and atypical PKCs (aPKCs) increased at the cardiac hypertrophy stage, but this increase tended to decline at the congestive heart failure stage. These results suggest that there are two groups of PKC isoforms. Several reports have shown that PKCα, β, and δ are involved in the development of cardiac hypertrophy and heart failure, and that PKCε plays a role in the physiological hypertrophic responses and cardioprotective actions. These facts suggest that all PKC isoforms (PKCα, β, δ, ε, and aPKCs) expressed in the heart may have similar functions at the cardiac hypertrophy stage, but that two groups of PKC isoforms (PKCα, β, δ, and PKCε, aPKCs) have different functions at the congestive heart failure stage. (Hypertens Res 2003; 26: 421-426)

Content from these authors
© 2003 by the Japanese Society of Hypertension
Previous article Next article
feedback
Top