Regular ArticleNeonatal handling in rats induces long-term effects on dynorphin peptides
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The impact of early-life environment on absence epilepsy and neuropsychiatric comorbidities
2022, IBRO Neuroscience ReportsCitation Excerpt :This means that neonatal handling which can modulate the GABAergic brain system may also modify acquired or genetic epilepsy. Neonatal handling-induced changes are reported not only in the GABAergic (Caldji et al., 2000) brain system, but also in monoaminergic (Durand et al., 1998; Papaioannou et al., 2002a,b), cholinergic (Pondiki et al., 2006), and opioid neurotransmitter systems (Ploj et al., 1999), all known to modulate epilepsies, including the frequency of occurrence of SWDs in WAG/Rij rats (van Luijtelaar and Zobeiri, 2014; Russo et al., 2016). Neonatal handling could modify the development of the HPA axis and, as a consequence, its response to different stressors.
Early life maternal deprivation attenuates morphine induced inhibition in lateral paragigantocellularis neurons in adult rats
2021, Brain Research BulletinCitation Excerpt :Emerging evidence indicates that mice lacking the mu-opioid receptors (MORs) exhibit deficient attachment behavior (Moles et al., 2004). Besides, it has been previously released that repeated short and long periods of MD elicits long-term effects on the brain opioidergic system (Gustafsson et al., 2008; Ploj and Nylander, 2003; Ploj et al., 1999, 2001; Ploj et al., 2003; Vazquez et al., 2005). This could indicate a reciprocal link between exposure to early life MD and dysregulation of the opioid system.
Anxiety-like behavior and other consequences of early life stress in mice with increased protein kinase A activity
2018, Behavioural Brain ResearchEarly maternal separation and responsiveness to thermal nociception in rodent offspring: A meta-analytic review
2016, Behavioural Brain ResearchNeonatal tactile stimulation alleviates the negative effects of neonatal isolation on novel object recognition, sociability and neuroendocrine levels in male adult mandarin voles (Microtus mandarinus)
2013, Physiology and BehaviorCitation Excerpt :Neonatal handing, such as an early tactile stimulation, has been demonstrated to affect behavioral and physiological responses to stress. For example, neonatal handling reduces anxiety-like behavior in an elevated plus maze [3] and induces resistance of the hypothalamus–pituitary–adrenal (HPA) axis to stress in adult rats [4]. Similarly, artificial licking-like tactile stimulation to rat pups reduces behavioral indices of anxiety, improves social learning, and increases curiosity and problem-solving abilities and even dramatically altered dendritic morphology in the prefrontal cortex and amygdale [5,6].
Altered levels of synapsin I, dopamine transporter, dynorphin A, and neuropeptide Y in the nucleus accumbens and striatum at post-puberty in rats treated neonatally with pregnenolone or DHEA
2009, International Journal of Developmental NeuroscienceCitation Excerpt :Learned helplessness rats, an animal model of depression, show an elevation of dynorphins in the nucleus accumbens core and shell and κ-opioid receptor antagonists exert antidepressive-like effects within the nucleus accumbens (Shirayama et al., 2004). Neonatally handled rats show an increase in dynorphin A in several brain regions including the striatum and exhibited attenuated fearfulness (Ploj et al., 1999). In addition, κ-opioid receptor agonism appears to reduce DA release in the nucleus accumbens (Herz, 1997; Spanagel et al., 1992).