Elsevier

Respiratory Medicine

Volume 95, Issue 2, February 2001, Pages 115-121
Respiratory Medicine

Regular Article
In patients with chronic bronchitis a four week trial with inhaled steroids does not attenuate airway inflammation

https://doi.org/10.1053/rmed.2000.0960Get rights and content
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Abstract

Systemic corticosteroids have been recommended as a therapeutic option in patients with moderate to severe COPD. In an early stage of the disease, i.e. chronic bronchitis with mild or no airflow obstruction, a trial with inhaled steroids could reveal potential benefits, particularly in terms of a modulation of airway inflammation.

We therefore investigated the effect of inhaled fluticasone (1000 μ g day−1) on markers of airway inflammation in 19 patients with chronic bronchitis (mean±SEM FEV1, 83·4±3·0% predicted; FEV1/VC, 67·5±2·4%) in a double-blind, cross-over, placebo-controlled manner. Visits were performed before and after two 4-week treatment periods, separated by a 4-week washout period. Lung function, the concentration of exhaled nitric oxide, differential cell counts in induced sputum and the number of cells positive for iNOS, as well as the levels of LDH, ECP, neutrophil elastase and IL-8 in sputum supernatants were determined.

Although the total cell number decreased significantly after fluticasone (geometric mean 12·3 vs. 7·7×106/ml;P<0·05) it was not significantly different from the change observed after placebo (14·2 vs. 10·6×106/ml; n.s.). None of the other parameters showed statistically significant changes after fluticasone or placebo and the results did not depend on the presence of airway hyperresponsiveness.

We conclude that in patients with chronic bronchitis short-term treatment with inhaled corticosterids did not improve lung function or inflammatory parameters to an extent which was statistically significant as compared to spontaneous variability.

Keywords

chronic bronchitis
chronic airway obstruction
inhaled glucocorticosteroids
fluticasone
inducible nitric oxide synthase (iNOS)
exhaled nitric oxide (NO)
induced sputum.

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Correspondence should be addressed to: Prof. Helgo Magnussen, Krankenhaus Grosshansdorf, Zentrum für Pneumologie und Thoraxchirurgie, Wöhrendamm 80, D-22927 Grosshansdorf, Germany. Fax: + 49 (0)4102 601 245; E-mail: [email protected]