Clinical–Liver, Pancreas, and Biliary TractAlterations in Adipose Tissue and Hepatic Lipid Kinetics in Obese Men and Women With Nonalcoholic Fatty Liver Disease
Section snippets
Subjects
Twenty-eight obese subjects participated in this study: 14 subjects had NAFLD (IHTG >10% of liver volume) and 14 subjects had normal intrahepatic fat content (IHTG ≤5.5% of liver volume)9 (Table 1). Groups with NAFLD and normal IHTG content were matched on age, sex, BMI, and percent body fat. All subjects completed a comprehensive medical evaluation, which included a detailed history and physical examination, routine blood tests, a 12-lead electrocardiogram, and a 2-hour oral glucose tolerance
Demographics and Body Composition
Subjects who had NAFLD and those with normal IHTG content were matched on age, sex, body weight, BMI, and percent body fat (Table 1). The amount of IHTG ranged from 1.3% to 5.4% in the normal IHTG group and from 13.9% to 22.7% in the NAFLD group. Abdominal subcutaneous fat volume was similar between groups, whereas intra-abdominal fat volume was ∼75% greater in subjects who had NAFLD than those with normal IHTG (Table 1).
Metabolic and Biochemical Variables
Plasma glucose concentration was not different between groups, but plasma
Discussion
Alterations in hepatic lipoprotein metabolism are likely involved in the pathogenesis and pathophysiology of NAFLD. However, the relationship between NAFLD and VLDL kinetics is not clear because of conflicting results from different studies. The reason for these discordant findings might be related to differences in study subject characteristics that can independently affect hepatic lipoprotein metabolism. In the present study, we evaluated the key physiologic factors involved in the
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Supported by National Institutes of Health grants DK 37948, DK 56341 (Clinical Nutrition Research Unit), RR-00036 (General Clinical Research Center), and RR-00954 (Biomedical Mass Spectrometry Resource) and by an AGA-Roche Junior Faculty Clinical Research Award in Hepatology.
Conflicts of interest: No conflicts of interests exist.