Basic-alimentary tractVisceral hyperalgesia and intestinal dysmotility in a mouse model of postinfective gut dysfunction☆
Section snippets
Animals
The experimental procedure was approved by the Animal Welfare Committee of McMaster University Medical Center. Specific pathogen-free female NIH Swiss mice, 6–8 weeks old, were purchased from National Cancer Institute (Frederick, MD). Groups of mice were assigned to motility, colorectal distention (CRD), and single unit discharge recording experiments. Both motility and CRD experiments were performed in additional mice after T. spiralis antigen challenge. Mice were killed at different time
Acknowledgements
The authors thank Alfred Bayatti (AstraZeneca, Molndal, Sweden) for his expertise and help in establishing technique for visceral hyperalgesia assessment in our laboratory and Mary Jo Smith (Dept. of Pathology, McMaster University) for help and advice in immunohistochemistry.
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Supported by Canadian Institutes of Health Research (CIHR) and AstraZeneca, Molndal, Sweden.