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The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition

Oncogene volume 26, pages 3227–3239 (2007)Cite this article

Abstract

The Ras-dependent extracellular signal-regulated kinase (ERK)1/2 mitogen-activated protein (MAP) kinase pathway plays a central role in cell proliferation control. In normal cells, sustained activation of ERK1/ERK2 is necessary for G1- to S-phase progression and is associated with induction of positive regulators of the cell cycle and inactivation of antiproliferative genes. In cells expressing activated Ras or Raf mutants, hyperactivation of the ERK1/2 pathway elicits cell cycle arrest by inducing the accumulation of cyclin-dependent kinase inhibitors. In this review, we discuss the mechanisms by which activated ERK1/ERK2 regulate growth and cell cycle progression of mammalian somatic cells. We also highlight the findings obtained from gene disruption studies.

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Acknowledgements

S Meloche holds a Canada Research Chair in Cellular Signaling. Work in the author's laboratory was supported by grants from the National Cancer Institute of Canada, Canadian Institutes for Health Research and Cancer Research Society to SM, and by the Centre National de la Recherche Scientifique, Centre A Lacassagne, Ministère de l'Education, de la Recherche et de la Technologie, Ligue Nationale Contre le Cancer (Equipe labellisée) and Association pour la Recherche sur le Cancer to JP.

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  1. Departments of Pharmacology and Molecular Biology, Institut de Recherche en Immunologie et Cancérologie, Université de Montréal, Montreal, Quebec, Canada

    S Meloche

  2. Institute of Signaling, Developmental Biology and Cancer, CNRS UMR 6543, Université de Nice-Sofia Antipolis, Centre A., Lacassagne, Nice, France

    J Pouysségur

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Meloche, S., Pouysségur, J. The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition. Oncogene 26, 3227–3239 (2007). https://doi.org/10.1038/sj.onc.1210414

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