Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Review
  • Published:

Pocket proteins and cell cycle control

Abstract

The retinoblastoma protein (pRB) and the pRB-related p107 and p130 comprise the ‘pocket protein’ family of cell cycle regulators. These proteins are best known for their roles in restraining the G1–S transition through the regulation of E2F-responsive genes. pRB and the p107/p130 pair are required for the repression of distinct sets of genes, potentially due to their selective interactions with E2Fs that are engaged at specific promoter elements. In addition to regulating E2F-responsive genes in a reversible manner, pocket proteins contribute to silencing of such genes in cells that are undergoing senescence or differentiation. Pocket proteins also affect the G1–S transition through E2F-independent mechanisms, such as by inhibiting Cdk2 or by stabilizing p27Kip1, and they are implicated in the control of G0 exit, the spatial organization of replication, and genomic rereplication. New insights into pocket protein regulation have also been obtained. Kinases previously thought to be crucial to pocket protein phosphorylation have been shown to be redundant, and new modes of phosphorylation and dephosphorylation have been identified. Despite these advances, much remains to be learned about the pocket proteins, particularly with regard to their developmental and tumor suppressor functions. Thus continues the story of the pocket proteins and the cell cycle.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2
Figure 3
Figure 4

Similar content being viewed by others

References

  • Abramson DH . (1999). Ophthalmic Genet., 20, 193–204.

  • Ait-Si-Ali S, Guasconi V, Fritsch L, Yahi H, Sekhri R, Naguibneva I, Robin P, Cabon F, Polesskaya A and Harel-Bellan A . (2004). EMBO J., 23, 605–615.

  • Alevizopoulos K, Vlach J, Hennecke S and Amati B . (1997). EMBO J., 16, 5322–5333.

  • Alexander K and Hinds PW . (2001). Mol. Cell. Biol., 21, 3616–3631.

  • Araki K, Nakajima Y, Eto K and Ikeda MA . (2003). Oncogene, 22, 7632–7641.

  • Aslanian A, Iaquinta PJ, Verona R and Lees JA . (2004). Genes Dev., 18, 1413–1422.

  • Avni D, Yang H, Martelli F, Hofmann F, ElShamy WM, Ganesan S, Scully R and Livingston DM . (2003). Mol. Cell, 12, 735–746.

  • Barbie DA, Kudlow BA, Frock R, Zhao J, Johnson BR, Dyson N, Harlow E and Kennedy BK . (2004). Mol. Cell. Biol., 24, 595–607.

  • Berthet C, Aleem E, Coppola V, Tessarollo L and Kaldis P . (2003). Curr. Biol., 13, 1775–1785.

  • Black EP, Huang E, Dressman H, Rempel R, Laakso N, Asa SL, Ishida S, West M and Nevins JR . (2003). Cancer Res., 63, 3716–3723.

  • Blais A and Dynlacht BD . (2004). Curr. Opin. Genet. Dev., 14, 527–532.

  • Blow JJ and Hodgson B . (2002). Trends Cell Biol., 12, 72–78.

  • Bosco G, Du W and Orr-Weaver TL . (2001). Nat. Cell Biol., 3, 289–295.

  • Botz J, Zerfass-Thome K, Spitkovsky D, Delius H, Vogt B, Eilers M, Hatzigeorgiou A and Jansen-Durr P . (1996). Mol. Cell. Biol., 16, 3401–3409.

  • Bracken AP, Ciro M, Cocito A and Helin K . (2004). Trends Biochem. Sci., 29, 409–417.

  • Buchkovich K, Duffy LA and Harlow E . (1989). Cell, 58, 1097–1105.

  • Cam H and Dynlacht BD . (2003). Cancer Cell, 3, 311–316.

  • Cavanaugh AH, Hempel WM, Taylor LJ, Rogalsky V, Todorov G and Rothblum LI . (1995). Nature, 374, 177–180.

  • Cavenee WK, Dryja TP, Phillips RA, Benedict WF, Godbout R, Gallie BL, Murphree AL, Strong LC and White RL . (1983). Nature, 305, 779–784.

  • Cayirlioglu P, Ward WO, Silver Key SC and Duronio RJ . (2003). Mol. Cell. Biol., 23, 2123–2134.

  • Chen CR, Kang Y, Siegel PM and Massague J . (2002). Cell, 110, 19–32.

  • Chen D, Livne-bar I, Vanderluit JL, Slack RS, Agochiya M and Bremner R . (2004). Cancer Cell, 5, 539–551.

  • Chibazakura T, McGrew SG, Cooper JA, Yoshikawa H and Roberts JM . (2004). Proc. Natl. Acad. Sci. USA, 101, 4465–4470.

  • Cicchillitti L, Fasanaro P, Biglioli P, Capogrossi MC and Martelli F . (2003). J. Biol. Chem., 278, 19509–19517.

  • Classon M and Dyson N . (2001). Exp. Cell Res., 264, 135–147.

  • Coats S, Whyte P, Fero ML, Lacy S, Chung G, Randel E, Firpo E and Roberts JM . (1999). Curr. Biol., 9, 163–173.

  • Cobrinik D . (1996). Curr. Top. Microbiol. Immunol., 208, 31–60.

  • Cobrinik D, Dowdy SF, Hinds PW, Mittnacht S and Weinberg RA . (1992). Trends Biochem. Sci., 17, 312–315.

  • Coisy M, Roure V, Ribot M, Philips A, Muchardt C, Blanchard JM and Dantonel JC . (2004). Mol. Cell, 15, 43–56.

  • Coverley D, Laman H and Laskey RA . (2002). Nat. Cell Biol., 4, 523–528.

  • Dahiya A, Wong S, Gonzalo S, Gavin M and Dean DC . (2001). Mol. Cell, 8, 557–569.

  • Dahiya A, Wong S, Gonzalo S, Gavin M and Dean DC . (2003). Mol. Cell, 11, 1693–1696.

  • Dailey L, Laplantine E, Priore R and Basilico C . (2003). J. Cell Biol., 161, 1053–1066.

  • Dannenberg JH, van Rossum A, Schuijff L and te Riele H . (2000). Genes Dev., 14, 3051–3064.

  • DeCaprio JA, Ludlow JW, Lynch D, Furukawa Y, Griffin J, Piwnica-Worms H, Huang C-M and Livingston DM . (1989). Cell, 58, 1085–1095.

  • Dimova DK and Dyson N . (2005). Oncogene, 24,2810–2826.

  • Dimova DK, Stevaux O, Frolov MV and Dyson NJ . (2003). Genes Dev., 17, 2308–2320.

  • Di Leonardo A, Khan SH, Linke SP, Greco V, Seidita G and Wahl GM . (1997). Cancer Res., 57, 1013–1019.

  • Di Stefano L, Jensen MR and Helin K . (2003). EMBO J., 22, 6289–6298.

  • Dunaief JL, Strober BE, Guha S, Khavari PA, Alin K, Luban J, Begemann M, Crabtree GR and Goff SP . (1994). Cell, 79, 119–130.

  • Dunn JM, Phillips RA, Becker AJ and Gallie BL . (1988). Science, 241, 1797–1800.

  • Dyson N . (1998). Genes Dev., 12, 2245–2262.

  • Fabbrizio E, El Messaoudi S, Polanowska J, Paul C, Cook JR, Lee JH, Negre V, Rousset M, Pestka S, Le Cam A and Sardet C . (2002). EMBO Rep., 3, 641–645.

  • Falls H and Neel J . (1951). Arch. Ophthalmol., 46, 367–389.

  • Fang W, Mori T and Cobrinik D . (2002). Oncogene, 21, 5557–5565.

  • Ferreira R, Naguibneva I, Mathieu M, Ait-Si-Ali S, Robin P, Pritchard LL and Harel-Bellan A . (2001). EMBO Rep., 2, 794–799.

  • Flemington EK, Speck SH and Kaelin Jr WG . (1993). Proc. Natl. Acad. Sci. USA, 90, 6914–6918.

  • Friend SH, Bernards R, Rogelj S, Weinberg RA, Rapaport JM, Alberts D and Dryja TP . (1986). Nature, 323, 643–646.

  • Frolov MV and Dyson NJ . (2004). J. Cell Sci., 117, 2173–2181.

  • Gagrica S, Hauser S, Kolfschoten I, Osterloh L, Agami R and Gaubatz S . (2004). EMBO J., 23, 4627–4638.

  • Garnovskaya MN, Mukhin YV, Vlasova TM, Grewal JS, Ullian ME, Tholanikunnel BG and Raymond JR . (2004). J. Biol. Chem., 279, 24899–24905.

  • Geng Y, Whoriskey W, Park MY, Bronson RT, Medema RH, Li T, Weinberg RA and Sicinski P . (1999). Cell, 97, 767–777.

  • Geng Y, Yu Q, Sicinska E, Das M, Schneider JE, Bhattacharya S, Rideout WM, Bronson RT, Gardner H and Sicinski P . (2003). Cell, 114, 431–443.

  • Ghosh MK and Harter ML . (2003). Mol. Cell, 12, 255–260.

  • Giangrande PH, Zhu W, Rempel RE, Laakso N and Nevins JR . (2004). EMBO J., 23, 1336–1347.

  • Ginsberg D . (2004). Dev. Cell, 6, 742–743.

  • Hanahan D and Weinberg RA . (2000). Cell, 100, 57–70.

  • Hannan KM, Kennedy BK, Cavanaugh AH, Hannan RD, Hirschler-Laszkiewicz I, Jefferson LS and Rothblum LI . (2000). Oncogene, 19, 3487–3497.

  • Harbour JW . (2001). Arch. Ophthalmol., 119, 1699–1704.

  • Harbour JW, Lai S-L, Whang-Peng J, Gazder AF, Minna JD and Kaye FJ . (1988). Science, 241, 353–357.

  • Harbour JW, Luo RX, Dei Santi A, Postigo AA and Dean DC . (1999). Cell, 98, 859–869.

  • Harrington EA, Bruce JL, Harlow E and Dyson N . (1998). Proc. Natl. Acad. Sci. USA, 95, 11945–11950.

  • Hatakeyama M, Brill JA, Fink GR and Weinberg RA . (1994). Genes Dev., 8, 1759–1771.

  • He S, Cook BL, Deverman BE, Weihe U, Zhang F, Prachand V, Zheng J and Weintraub SJ . (2000). Mol. Cell. Biol., 20, 363–371.

  • Helin K, Harlow E and Fattaey AR . (1993). Mol. Cell. Biol., 13, 6501–6508.

  • Hernando E, Nahle Z, Juan G, Diaz-Rodriguez E, Alaminos M, Hemann M, Michel L, Mittal V, Gerald W, Benezra R, Lowe SW and Cordon-Cardo C . (2004). Nature, 430, 797–802.

  • Herrera RE, Tan VP, Williams BO, Makela T, Weinberg RA and Jacks T . (1996). Mol. Cell. Biol., 16, 2402–2407.

  • Horowitz JM, Yandell DW, Park S-H, Canning S, Whyte P, Buchkovich K, Harlow E, Weinberg RA and Dryja TP . (1989). Science, 243, 937–940.

  • Hou ST, Xie X, Baggley A, Park DS, Chen G and Walker T . (2002). J. Biol. Chem., 277, 48764–48770.

  • Hsu JY, Reimann JD, Sorensen CS, Lukas J and Jackson PK . (2002). Nat. Cell Biol., 4, 358–366.

  • Huh MS, Parker MH, Scime A, Parks R and Rudnicki MA . (2004). J. Cell Biol., 166, 865–876.

  • Hurford RK, Cobrinik D, Lee MH and Dyson N . (1997). Genes Dev., 11, 1447–1463.

  • Ishida S, Huang E, Zuzan H, Spang R, Leone G, West M and Nevins JR . (2001). Mol. Cell. Biol., 21, 4684–4699.

  • Ji P, Jiang H, Rekhtman K, Bloom J, Ichetovkin M, Pagano M and Zhu L . (2004). Mol. Cell, 16, 47–58.

  • Karantza V, Maroo A, Fay D and Sedivy JM . (1993). Mol. Cell. Biol., 13, 6640–6652.

  • Karlseder J, Rotheneder H and Wintersberger E . (1996). Mol. Cell. Biol., 16, 1659–1667.

  • Kennedy BK, Barbie DA, Classon M, Dyson N and Harlow E . (2000). Genes Dev., 14, 2855–2868.

  • Knudson AG . (1971). Proc. Natl. Acad. Sci. USA, 68, 820–823.

  • Knudsen KE, Booth D, Naderi S, Sever-Chroneos Z, Fribourg AF, Hunton IC, Feramisco JR, Wang JY and Knudsen ES . (2000). Mol. Cell. Biol., 20, 7751–7763.

  • Kondo T, Higashi H, Nishizawa H, Ishikawa S, Ashizawa S, Yamada M, Makita Z, Koike T and Hatakeyama M . (2001). J. Biol. Chem., 276, 17559–17567.

  • Kozar K, Ciemerych MA, Rebel VI, Shigematsu H, Zagozdzon A, Sicinska E, Geng Y, Yu Q, Bhattacharya S, Bronson RT, Akashi K and Sicinski P . (2004). Cell, 118, 477–491.

  • Ladd AC, Pyatt R, Gothot A, Rice S, McMahel J, Traycoff CM and Srour EF . (1997). Blood, 90, 658–668.

  • Lai A, Kennedy BK, Barbie DA, Bertos NR, Yang XJ, Theberge MC, Tsai SC, Seto E, Zhang Y, Kuzmichev A, Lane WS, Reinberg D, Harlow E and Branton PE . (2001). Mol. Cell. Biol., 21, 2918–2932.

  • Lajtha LG . (1963). J. Cell Physiol., 62 (Suppl. 1), 143–145.

  • Lan Z, Sever-Chroneos Z, Strobeck MW, Park CH, Baskaran R, Edelmann W, Leone G and Knudsen ES . (2002). J. Biol. Chem., 277, 8372–8381.

  • Lanni JS and Jacks T . (1998). Mol. Cell. Biol., 18, 1055–1064.

  • Laplantine E, Rossi F, Sahni M, Basilico C and Cobrinik D . (2002). J. Cell Biol., 158, 741–750.

  • Le Cam L, Polanowska J, Fabbrizio E, Olivier M, Philips A, Ng Eaton E, Classon M, Geng Y and Sardet C . (1999). EMBO J., 18, 1878–1890.

  • Lee EY, Cam H, Ziebold U, Rayman JB, Lees JA and Dynlacht BD . (2002). Cancer Cell, 2, 463–472.

  • Lee EY-HP, To H, Shew J-Y, Bookstein R, Scully P and Lee W-H . (1988). Science, 241, 218–221.

  • Lee KY, Ladha MH, McMahon C and Ewen ME . (1999). Mol. Cell. Biol., 19, 7724–7732.

  • Lee W-H, Shew J-Y, Hong FD, Sery TW, Donoso LA, Young L-J, Bookstein R and Lee EY-H . (1987). Nature, 329, 642–645.

  • Leng X, Connell-Crowley L, Goodrich D and Harper JW . (1997). Curr. Biol., 7, 709–712.

  • Leone G, Nuckolls F, Ishida S, Adams M, Sears R, Jakoi L, Miron A and Nevins JR . (2000). Mol. Cell. Biol., 20, 3626–3632.

  • Lin SY, Black AR, Kostic D, Pajovic S, Hoover CN and Azizkhan JC . (1996). Mol. Cell. Biol., 16, 1668–1675.

  • Liu H, Dibling B, Spike B, Dirlam A and Macleod K . (2004). Curr. Opin. Genet. Dev., 14, 55–64.

  • Ludlow JW, Glendening CL, Livingston DM and DeCarprio JA . (1993). Mol. Cell. Biol., 13, 367–372.

  • Lukas J, Herzinger T, Hansen K, Moroni MC, Resnitzky D, Helin K, Reed SI and Bartek J . (1997). Genes Dev., 11, 1479–1492.

  • Lundberg AS and Weinberg RA . (1998). Mol. Cell. Biol., 18, 753–761.

  • Ma D, Zhou P and Harbour JW . (2003). J. Biol. Chem., 278, 19358–19366.

  • MacPherson D, Sage J, Kim T, Ho D, McLaughlin ME and Jacks T . (2004). Genes Dev., 18, 1681–1694.

  • Maddison LA, Sutherland BW, Barrios RJ and Greenberg NM . (2004). Cancer Res., 64, 6018–6025.

  • Malumbres M, Sotillo R, Santamaria D, Galan J, Cerezo A, Ortega S, Dubus P and Barbacid M . (2004). Cell, 118, 493–504.

  • Margottin-Goguet F, Hsu JY, Loktev A, Hsieh HM, Reimann JD and Jackson PK . (2003). Dev. Cell, 4, 813–826.

  • Marino S, Hoogervoorst D, Brandner S and Berns A . (2003). Development, 130, 3359–3368.

  • Meuwissen R, Linn SC, Linnoila RI, Zevenhoven J, Mooi WJ and Berns A . (2003). Cancer Cell, 4, 181–189.

  • Mittnacht S . (1998). Curr. Opin. Genet. Dev., 8, 21–27.

  • Morris EJ and Dyson NJ . (2001). Adv. Cancer Res., 82, 1–54.

  • Morrison AJ, Sardet C and Herrera RE . (2002). Mol. Cell. Biol., 22, 856–865.

  • Muller H, Bracken AP, Vernell R, Moroni MC, Christians F, Grassilli E, Prosperini E, Vigo E, Oliner JD and Helin K . (2001). Genes Dev., 15, 267–285.

  • Mulligan GJ, Wong J and Jacks T . (1998). Mol. Cell. Biol., 18, 206–220.

  • Narita M, Nunez S, Heard E, Lin AW, Hearn SA, Spector DL, Hannon GJ and Lowe SW . (2003). Cell, 113, 703–716.

  • Narlikar GJ, Fan HY and Kingston RE . (2002). Cell, 108, 475–487.

  • Nath N, Wang S, Betts V, Knudsen E and Chellappan S . (2003). Oncogene, 22, 5986–5994.

  • Nevins JR . (1992). Science, 258, 424–429.

  • Nevins JR . (1998). Cell Growth Differ., 9, 585–593.

  • Nguyen DX, Baglia LA, Huang SM, Baker CM and McCance DJ . (2004). EMBO J., 23, 1609–1618.

  • Nicolas E, Roumillac C and Trouche D . (2003). Mol. Cell. Biol., 23, 1614–1622.

  • Niculescu III AB, Chen X, Smeets M, Hengst L, Prives C and Reed SI . (1998). Mol. Cell. Biol., 18, 629–643.

  • Nielsen SJ, Schneider R, Bauer UM, Bannister AJ, Morrison A, O'Carroll D, Firestein R, Cleary M, Jenuwein T, Herrera RE and Kouzarides T . (2001). Nature, 412, 561–565.

  • Ogawa H, Ishiguro K, Gaubatz S, Livingston DM and Nakatani Y . (2002). Science, 296, 1132–1136.

  • Ortega S, Prieto I, Odajima J, Martin A, Dubus P, Sotillo R, Barbero JL, Malumbres M and Barbacid M . (2003). Nat. Genet., 35, 25–31.

  • Otterson GA, Chen W, Coxon AB, Khleif SN and Kaye FJ . (1997). Proc. Natl. Acad. Sci. USA, 94, 12036–12040.

  • Pagano M and Jackson PK . (2004). Cell, 118, 535–538.

  • Pediconi N, Ianari A, Costanzo A, Belloni L, Gallo R, Cimino L, Porcellini A, Screpanti I, Balsano C, Alesse E, Gulino A and Levrero M . (2003). Nat. Cell Biol., 5, 552–558.

  • Peters AH, Kubicek S, Mechtler K, O'Sullivan RJ, Derijck AA, Perez-Burgos L, Kohlmaier A, Opravil S, Tachibana M, Shinkai Y, Martens JH and Jenuwein T . (2003). Mol. Cell, 12, 1577–1589.

  • Philips A, Huet X, Plet A, Le Cam L, Vie A and Blanchard JM . (1998). Oncogene, 16, 1373–1381.

  • Polager S, Kalma Y, Berkovich E and Ginsberg D . (2002). Oncogene, 21, 437–446.

  • Polanowska J, Fabbrizio E, Le Cam L, Trouche D, Emiliani S, Herrera R and Sardet C . (2001). Oncogene, 20, 4115–4127.

  • Rayman JB, Takahashi Y, Indjeian VB, Dannenberg JH, Catchpole S, Watson RJ, te Riele H and Dynlacht BD . (2002). Genes Dev., 16, 933–947.

  • Ren B, Cam H, Takahashi Y, Volkert T, Terragni J, Young RA and Dynlacht BD . (2002). Genes Dev., 16, 245–256.

  • Ren S and Rollins BJ . (2004). Cell, 117, 239–251.

  • Rice JC, Briggs SD, Ueberheide B, Barber CM, Shabanowitz J, Hunt DF, Shinkai Y and Allis CD . (2003). Mol. Cell, 12, 1591–1598.

  • Robanus-Maandag E, Dekker M, van der Valk M, Carrozza ML, Jeanny JC, Dannenberg JH, Berns A and te Riele H . (1998). Genes Dev., 12, 1599–1609.

  • Rossi F, MacLean HE, Yuan W, Francis RO, Semenova E, Lin CS, Kronenberg HM and Cobrinik D . (2002). Dev. Biol., 247, 271–285.

  • Royzman I, Austin RJ, Bosco G, Bell SP and Orr-Weaver TL . (1999). Genes Dev., 13, 827–840.

  • Ruiz S, Santos M, Segrelles C, Leis H, Jorcano JL, Berns A, Paramio JM and Vooijs M . (2004). Development, 131, 2737–2748.

  • Ruiz S, Segrelles C, Bravo A, Santos M, Perez P, Leis H, Jorcano JL and Paramio JM . (2003). Development, 130, 2341–2353.

  • Saavedra HI, Maiti B, Timmers C, Altura R, Tokuyama Y, Fukasawa K and Leone G . (2003). Cancer Cell, 3, 333–346.

  • Sage J, Miller AL, Perez-Mancera PA, Wysocki JM and Jacks T . (2003). Nature, 424, 223–228.

  • Sage J, Mulligan GJ, Attardi LD, Miller A, Chen S, Williams B, Theodorou E and Jacks T . (2000). Genes Dev., 14, 3037–3050.

  • Salomoni P and Pandolfi PP . (2002). Cell, 108, 165–170.

  • Schlisio S, Halperin T, Vidal M and Nevins JR . (2002). EMBO J., 21, 5775–5786.

  • Scott PH, Cairns CA, Sutcliffe JE, Alzuherri HM, McLees A, Winter AG and White RJ . (2001). J. Biol. Chem., 276, 1005–1014.

  • Sellers WR, Novitch BG, Miyake S, Heith A, Otterson GA, Kaye FJ, Lassar AB and Kaelin WG . (1998). Genes Dev., 12, 95–106.

  • Sever-Chroneos Z, Angus SP, Fribourg AF, Wan H, Todorov I, Knudsen KE and Knudsen ES . (2001). Mol. Cell. Biol., 21, 4032–4045.

  • Sherr CJ . (1996). Science, 274, 1672–1677.

  • Sherr CJ and Roberts JM . (2004). Genes Dev., 18, 2699–2711.

  • Siddiqui H, Solomon DA, Gunawardena RW, Wang Y and Knudsen ES . (2003). Mol. Cell. Biol., 23, 7719–7731.

  • Spruck CH, Wong K-A and Reed SI . (1999). Nature, 401, 297–300.

  • Sterner JM, Dew-Knight S, Musahl C, Kornbluth S and Horowitz JM . (1998). Mol. Cell. Biol., 18, 2748–2757.

  • Stevaux O and Dyson NJ . (2002). Curr. Opin. Cell Biol., 14, 684–691.

  • Strobeck MW, Knudsen KE, Fribourg AF, DeCristofaro MF, Weissman BE, Imbalzano AN and Knudsen ES . (2000). Proc. Natl. Acad. Sci. USA, 97, 7748–7753.

  • Strober BE, Dunaief JL and Guha Goff SP . (1996). Mol. Cell. Biol., 16, 1576–1583.

  • Takahashi Y, Rayman JB and Dynlacht BD . (2000). Genes Dev., 14, 804–816.

  • Taubert S, Gorrini C, Frank SR, Parisi T, Fuchs M, Chan HM, Livingston DM and Amati B . (2004). Mol. Cell. Biol., 24, 4546–4556.

  • Taylor-Harding B, Binne UK, Korenjak M, Brehm A and Dyson NJ . (2004). Mol. Cell. Biol., 24, 9124–9136.

  • Tedesco D, Lukas J and Reed SI . (2002). Genes Dev., 16, 2946–2957.

  • Thomas DM, Carty SA, Piscopo DM, Lee J, Wang W, Forrester WC and Hinds PW . (2001). Mol. Cell, 8, 303–316.

  • Trimarchi JM and Lees JA . (2002). Nat. Rev. Mol. Cell Biol., 3, 11–20.

  • Vandel L, Nicolas E, Vaute O, Ferreira R, Ait-Si-Ali S and Trouche D . (2001). Mol. Cell. Biol., 21, 6484–6494.

  • Vanderluit JL, Ferguson KL, Nikoletopoulou V, Parker M, Ruzhynsky V, Alexson T, McNamara SM, Park DS, Rudnicki M and Slack RS . (2004). J. Cell Biol., 166, 853–863.

  • Vooijs M, van der Valk M, te Riele H and Berns A . (1998). Oncogene, 17, 1–12.

  • Vuocolo S, Purev E, Zhang D, Bartek J, Hansen K, Soprano DR and Soprano KJ . (2003). J. Biol. Chem., 278, 41881–41889.

  • Wang S, Nath N, Minden A and Chellappan S . (1999). EMBO J., 18, 1559–1570.

  • Weinberg RA . (1995). Cell, 81, 323–330.

  • Weinmann AS, Yan PS, Oberley MJ, Huang TH and Farnham PJ . (2002). Genes Dev., 16, 235–244.

  • Wells J, Boyd KE, Fry CJ, Bartley SM and Farnham PJ . (2000). Mol. Cell. Biol., 20, 5797–5807.

  • White RJ . (1997). Trends Biochem. Sci., 22, 77–80.

  • Wikenheiser-Brokamp KA . (2004). Development, 131, 4299–4310.

  • Williams BO, Remington L, Albert DM, Mukai S, Bronson RT and Jacks T . (1994). Nat. Genet., 7, 480–484.

  • Wu L, de Bruin A, Saavedra HI, Starovic M, Trimboli A, Yang Y, Opavska J, Wilson P, Thompson JC, Ostrowski MC, Rosol TJ, Woollett LA, Weinstein M, Cross JC, Robinson ML and Leone G . (2003). Nature, 421, 942–947.

  • Wu L, Timmers C, Maiti B, Saavedra HI, Sang L, Chong GT, Nuckolls F, Giangrande P, Wright FA, Field SJ, Greenberg ME, Orkin S, Nevins JR, Robinson ML and Leone G . (2001). Nature, 414, 457–462.

  • Yam CH, Fung TK and Poon RY . (2002). Cell Mol. Life Sci., 59, 1317–1326.

  • Ye X, Zhu C and Harper JW . (2001). Proc. Natl. Acad. Sci. USA, 98, 1682–1686.

  • Zhang HS, Gavin M, Dahiya A, Postigo AA, Ma D, Luo RX, Harbour JW and Dean DC . (2000). Cell, 101, 79–89.

  • Zhang HS, Postigo AA and Dean DC . (1999). Cell, 97, 53–61.

  • Zhang J, Gray J, Wu L, Leone G, Rowan S, Cepko CL, Zhu X, Craft CM and Dyer MA . (2004a). Nat. Genet., 36, 351–360.

  • Zhang J, Schweers B and Dyer MA . (2004b). Cell Cycle, 3, 952–959.

  • Zhu L, Harlow E and Dynlacht BD . (1995). Genes Dev., 9, 1740–1752.

  • Zhu W, Giangrande PH and Nevins JR . (2004). EMBO J., 23, 4615–4626.

Download references

Acknowledgements

I thank Nick Dyson for helpful discussions and Marie Classon, Peter K Jackson, and Liang Zhu for discussing work prior to publication and critical reading of the manuscript. My apologies are given to those whose work could not be cited due to space considerations. I was supported by the CV Starr Foundation during the preparation of this review.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to David Cobrinik.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cobrinik, D. Pocket proteins and cell cycle control. Oncogene 24, 2796–2809 (2005). https://doi.org/10.1038/sj.onc.1208619

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.onc.1208619

Keywords

This article is cited by

Search

Quick links