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Jun, the oncoprotein

Oncogene volume 20, pages 2365–2377 (2001)Cite this article

Abstract

Cellular Jun (c-Jun) and viral Jun (v-Jun) can induce oncogenic transformation. For this activity, c-Jun requires an upstream signal, delivered by the Jun N-terminal kinase (JNK). v-Jun does not interact with JNK; it is autonomous and constitutively active. v-Jun and c-Jun address overlapping but not identical sets of genes. Whether all genes essential for transformation reside within the overlap of the v-Jun and c-Jun target spectra remains to be determined. The search for transformation-relevant targets of Jun is moving into a new stage with the application of DNA microarrays technology. Genetic screens and functional tests remain a necessity for the identification of genes that control the oncogenic phenotype.

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Acknowledgements

Research of the author is supported by grants from the National Cancer Institute, National Institutes of Health. Masa Aoki, Thorsten Berg, Weixing Chen, Jason Iacovoni, Barbara Kempf, Daniel Maslyar, Makoto Nishizawa, Corinna Sonderegger, Anke Waha and Mark Ware made valuable comments on the manuscript and generously tolerated the preoccupation of their mentor with this review. Special thanks are due to Anke Waha who compiled Table 1. This is manuscript number 13798-MEM from the Scripps Research Institute. This paper is dedicated to two charmingly independent and affectionate tabbies, Tampopo and Iris, who helped shorten and re-shorten the manuscript and the reference list.

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  1. Department of Molecular and Experimental Medicine, The Scripps Reasearch Institute, 10550 North Torrey Pines Drive, La Jolla, CA, 9203, California, USA

    Peter K Vogt

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Vogt, P. Jun, the oncoprotein. Oncogene 20, 2365–2377 (2001). https://doi.org/10.1038/sj.onc.1204443

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