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The cellular response to p53: the decision between life and death

Oncogene volume 18, pages 6145–6157 (1999)Cite this article

Abstract

The p53 tumor suppressor protein plays a crucial role in regulating cell growth following exposure to various stress stimuli. p53 induces either growth arrest, which prevents the replication of damaged DNA, or programmed cell death (apoptosis), which is important for eliminating defective cells. Whether the cell enters growth arrest or undergoes apoptosis, depends on the final integration of incoming signals with antagonistic effects on cell growth. Many factors affect the cellular response to activated p53. These include the cell type, the oncogenic status of the cell with emphasis on the Rb/E2F balance, the extracellular growth and survival stimuli, the intensity of the stress signals, the level of p53 expression and the interaction of p53 with specific proteins. p53 is regulated both at the levels of protein stability and biochemical activities. This complex regulation is mediated by a range of viral and cellular proteins. This review discusses this intriguing complexity which affects the cell response to p53 activation.

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Acknowledgements

The authors wish to thank Dr Sue Moody-Haupt for critical comments. Due to space limitations many original important studies have not been cited directly but rather through the relevant reviews. Work in the authors' laboratory is supported by the Basil O'Connor Starter Scholar Research Award Grant from the March of Dimes, by the Research Career Development Award from the Israel Cancer Research Fund and by a grant from the Israel Cancer Association.

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  1. Lautenberg Center for General and Tumor Immunology, The Hebrew University Hadassah Medical School, Jerusalem, 91120, Israel

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Sionov, R., Haupt, Y. The cellular response to p53: the decision between life and death. Oncogene 18, 6145–6157 (1999). https://doi.org/10.1038/sj.onc.1203130

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